Efg1, a morphogenetic regulator in Candida albicans, is a sequence-specific DNA binding protein.
نویسندگان
چکیده
Efg1 is essential for hyphal development in the human pathogen Candida albicans under most conditions. Efg1 is related to basic helix-loop-helix regulators, and therefore most workers presume that Efg1 is a transcription factor. Here we confirm that Efg1 is a DNA binding protein that can interact specifically with the E box.
منابع مشابه
Down-Regulation of the ALS3 Gene as a Consequent Effect of RNA-Mediated Silencing of the EFG1 Gene in Candida albicans
Background: The most important virulence factor which plays a central role in Candida albicans pathogenesis is the ability of this yeast to alternate between unicellular yeast and filamentous hyphal forms. Efg1 protein is thought to be the main positive regulating transcription factor, which is responsible for regulating hyphal-specific gene expression under most conditions. ALS3 is one of the ...
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ورودعنوان ژورنال:
- Journal of bacteriology
دوره 183 13 شماره
صفحات -
تاریخ انتشار 2001